![]() They cause rapid aging and a shortened life span: The changed genes that cause these syndromes are passed down in families. These conditions are called progeroid syndromes. There are other syndromes that may include problems with progerin-like proteins. In most cases, the rare gene change that causes progeria happens by chance. The changed gene that causes progeria is rarely passed down in families. Progerin makes cells unstable and appears to lead to progeria's aging process. When the LMNA gene has a change, a flawed lamin A protein called progerin is made. This gene, known as lamin A (LMNA), makes a protein that's needed to hold the center of a cell, called the nucleus, together. If you notice changes in your child that could be symptoms of progeria, or you have any concerns about your child's growth or development, make an appointment with your child's health care provider.Ī change in one gene causes progeria. This often happens at regular checkups, when a baby first shows the distinctive signs of premature aging. Progeria is usually found in infancy or early childhood. Insulin resistance, which means the body doesn't respond well to insulin made by an organ called the pancreas.A hip that's forced out of the correct position, known as hip dislocation.Joint problems, including stiff joints.Problems with the growth and development of bones.Loss of fat under the skin and loss of muscle.Delayed tooth formation and tooth shape that is not usual.Severe progressive heart and blood vessel disease, also known as cardiovascular disease.Hair loss, including eyelashes and eyebrows.Large eyes and eyelids that don't close completely.Thin, curved nose with a slight hook at the end, which may look like a bird's beak. ![]() Small jaw, chin and mouth and thin lips.Head that is large compared with the face.Lack of fat that's stored just beneath the skin. ![]()
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